Cryoprecipitate is a concentrated blood component made from plasma, usually a cloudy yellow colour.(1)
It contains specific proteins involved in clotting.
Blood clotting proteins found in cryoprecipitate include:(1)
Factor VIII (the protein missing in patients with Haemophilia A)
Cryoprecipitate is a source of fibrinogen. Fibrinogen is vital to blood clotting.
It is usually used in the treatment of patients with reduced levels of, or poorly functioning, fibrinogen with clinical bleeding, an invasive procedure or trauma.
There are alternatives to receiving a blood transfusion and are used whenever possible.
If you wish to avoid receiving a blood transfusion for religious or personal objections, it is extremely important to talk with your doctor about this.
The transfusion will be given through an IV, also known as a drip, a soft plastic tube in either your arm or hand.
A cryoprecipitate dose usually includes more than one pack. Each dose is usually given over a 10 to 30 minute period in a stable adult patient.(2)
A dose must not exceed an infusion time of greater than 4 hours.(2)
Adverse reactions are rare but can occur.
Types of reactions that may be experienced include:(2)
Mild allergy: Symptoms can include hives, rash or itching.
Febrile: Symptoms can include fever accompanied with chills and shaking.
Acute haemolytic: Symptoms can include shaking, fever, pain at the IV site, low blood pressure, unexplained bleeding, fast or irregular heartbeat, shortness of breath and decreased urine production.
Transfusion-related Acute Lung Injury (TRALI): symptoms can include chills, fever, shortness of breath; respiratory failure and fluid build up in the lungs.
Severe allergy: Symptoms can include flushing, wheezing, low blood pressure or anaphylaxis.
You should notify your healthcare professional if you experience any of the symptoms listed above during or after your transfusion.
All blood components in Australia come from voluntary unpaid donors attending the Australian Red Cross Blood Service.
Donors undergo a careful screening process to ensure that is appropriate for them to donate blood.
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Von Willebrand factor